Histomorphololgical effects of aqueous extract of ginger (rhizome) on the liver and kidney after paracetamol toxicity

Ebeye, O.A and Ekundina, V .O. and Ugbeh, I. (2014) Histomorphololgical effects of aqueous extract of ginger (rhizome) on the liver and kidney after paracetamol toxicity. Asian Journal of Biological and Life Sciences, 3 (1). pp. 1-6.

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Abstract

This study accessed the Histomorphological effect of the aqueous extract of ginger (rhizome) on the liver and kidney morphologies of an adult wistar rats after paracetamol toxicity . Twenty (20) adult wistar rats weighing between 150g-200g were assigned into four groups with five rats in each group. Group 1 served as negative control; while group two were given oral administration of paracetamol (150mg/150g) to induce toxicity , the third group was also given paracetamol at the same dose level as those in group two followed by oral administration of 1ml of the final aqueous extract of ginger (24mg/ml), and the fourth group served as positive control. Result revealed a slight reduction in the body weight of rat treated with paracetamol (group 2) while the body weight of group 1, 3 and 4 were not statistically significant. Histological, the result revealed that treating animals with paracetamol induced various histological changes in the liver and kidney morphologies. These changes include portal vein congestion, moderate pereportal and intarparenchymal fibrosis and moderate sclerosis of the glomeruli. Treating animals with the aqueous extract of ginger in paracetamol toxicity led to an improvement in the histological changes.

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