Modulation of antioxidant status in streptozotocin-induced diabetic male wistar rats following intake of red palm oil and/or rooibos

Ademola, Ayeleso and Nicole, Brooks and Oluwafemi, Oguntibeju (2014) Modulation of antioxidant status in streptozotocin-induced diabetic male wistar rats following intake of red palm oil and/or rooibos. Asian Pacific Journal of Tropical Medicine, 7 (7). pp. 536-544.

[img]
Preview
Text
Modulation of antioxidant status in streptozotocin-induced diabetic.pdf

Download (502kB) | Preview
Official URL: http://ac.els-cdn.com/

Abstract

Objective: To investigate the role of red palm oil (RPO), rooibos tea extract (RTE) and their combined treatment (RPO + RTE) on antioxidant status in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes mellitus was induced by a single administration of streptozotocin (50 mg/kg) and the rats were treated for 7 weeks. Antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)], antioxidant capacity [trolox equivalence antioxidant capacity (TEAC), oxygen radical absorbance capacity (ORAC)] as well as total protein, albumin, globulin, total glutathione, conjugated diene and thiobarbituric acid reactive substances (TBARS) were investigated. Results: Treatment with RPO, RTE and RPO + RTE significantly (p>0.05) improved liver SOD and plasma ORAC in the diabetic rats. Similarly, diabetic rats treated with RTE and RPO + RTE enhanced liver GPx. A significant (P<0.05) increase in the plasma TBARS in the diabetic control group was observed when compared with the normal control group. Treatment of diabetic rats with RTE and RPO + RTE reduced plasma TBARS to a level not significantly different at P<0.05 from the normal control group. Conclusions: The results revealed the anti-oxidative potentials of red palm oil, rooibos and their combination in diabetic conditions and hence, they could be useful in the management of diabetes and its complications.

Item Type: Article
Uncontrolled Keywords: Red palm oil Rooibos Antioxidant Streptozotocin Diabetes Rats
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QL Zoology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RD Surgery
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 28 Jun 2016 09:45
Last Modified: 28 Jun 2016 09:45
URI: http://eprints.abuad.edu.ng/id/eprint/1000

Actions (login required)

View Item View Item