Antioxidant Strategies in the Management of Diabetic Neuropathy

Ayodeji, Babatunde Oyenihi and Ademola, Olabode Ayeleso and Emmanuel, Mukwevho and Bubuya, Masola (2015) Antioxidant Strategies in the Management of Diabetic Neuropathy. BioMed Research International, 2015 (2015). pp. 1-16.

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Abstract

Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuropathy. Diabetic neuropathy (diabetes-induced nerve damage) is the most common diabetic complication and can be devastating because it can lead to disability. There is an increasing body of evidence associating diabetic neuropathy with oxidative stress. Oxidative stress results from the production of oxygen free radicals in the body in excess of its ability to eliminate them by antioxidant activity. Antioxidants have different mechanisms and sites of actions by which they exert their biochemical effects and ameliorate nerve dysfunction in diabetes by acting directly against oxidative damage.This review will examine different strategies for managing diabetic neuropathy which rely on exogenous antioxidants.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 28 Jun 2016 11:33
Last Modified: 28 Jun 2016 11:33
URI: http://eprints.abuad.edu.ng/id/eprint/1006

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