Evaluation Of Transaminases Activity Of Aqueous Extract Of Ocimum Gratissimum In The Liver And Kidney Of Albino Rats

Ojo, A.O. and Oloyede, O.I and Olarewaju, O.I and Ajiboye, B. O. (2013) Evaluation Of Transaminases Activity Of Aqueous Extract Of Ocimum Gratissimum In The Liver And Kidney Of Albino Rats. International Journal of Biological & Medical Research, 4 (4). pp. 3650-3653.

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Abstract

The effects of aqueous extract of Ocimum gratissimum on transaminases activity of albino rat were investigated. The objective was to evaluate the effects of aqueous extracts of fresh leaves of Ocimum gratissimum on transaminases activities in albino rats. Sixteen albino rats were randomly assigned to four experimental groups of 4 marked as control group, groups A, B, and C respectively. Groups A, B and C were treated with oral administration of aqueous extract of Ocimum gratissimum at 100mg, 200mg and 400mg/kg body weight daily respectively for two weeks. Control group received no treatment. Results showed that treatment of rats with the respective doses of the extract did not significantly alter the serum and liver levels of ALT and AST in all test groups. There was a significant increase in the activities (P<0.05) of AST and ALT in the kidney and the serum which might be caused by activation of enzymes synthesis in renal cells. The result suggests that ingestion of aqueous extract of Ocimum gratissimumcould confer protection on the liver tissues against injury, damage or disease and the extract may not be toxic at the doses investigated.

Item Type: Article
Uncontrolled Keywords: Ocimum gratissimum Alanine transaminase Aspartate transaminase Albino rats Aqueous extract Toxicological effect.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QL Zoology
Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Tayo Okunlola
Date Deposited: 30 Jun 2016 13:41
Last Modified: 30 Jun 2016 13:41
URI: http://eprints.abuad.edu.ng/id/eprint/1025

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