EFFECT OF ETHANOLIC EXTRACT OF ALSTONIA BOONEI LEAVES ON SERUM ELECTROLYTE LEVELS IN WISTAR ALBINO RATS.

Afolabi, B.A. and Obafemi, T.O. and Akinola, T.T. and Adeyemi, A.S. and Afolabi, O.B. (2014) EFFECT OF ETHANOLIC EXTRACT OF ALSTONIA BOONEI LEAVES ON SERUM ELECTROLYTE LEVELS IN WISTAR ALBINO RATS. PharmacologyOnline, 3. pp. 85-90. ISSN 1827-8620

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Abstract

This study evaluates the effect of methanol extract of Alstonia boonei leaves on levels of serum Mg2+, Ca2+, K+, Na+, HCO3-, urea and creatinine in wistar albino rats as a way of assessing the effect of the extract on kidney function. Twenty rats weighing 180-240 g were assigned to four groups (A, B, C and D) with five animals in each group. Group A served as the control while groups B, C and D served as the test groups and received 100 mg/kg, 200 mg/kg and 400 mg/kg of the extract respectively. All the animals were sacrificed after fourteen days of extract administration. Blood was collected by cardiac puncture for biochemical analysis of serum electrolytes. Serum chemistry showed that there was no significant difference (P<0.05) in the serum levels of bicarbonate, calcium, potassium and urea at all doses tested. Significantly raised sodium and decreased magnessium levels was observed in animals treated with 100mg/kgbw (P<0.05) however, the values were brought close to those of control at doses of 200 mg/kgbw and 400 mg/kgbw. The serum creatinine level was however significantly (P<0.05) higher than control at 400 mg/kgbw. From the result of this experiment, it is concluded that the administration of ethanolic extract of Alstonia boonei leaves does not alter the levels of serum electrolyte. However, care must be taken when exploring the medicinal value of the leaf because of the observed increased creatinine levels observed in the study.

Item Type: Article
Uncontrolled Keywords: – Biochemical, Electrolyte, Kidney, Serum, Alstonia boonei
Subjects: Q Science > Q Science (General)
Q Science > QK Botany
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Tayo Okunlola
Date Deposited: 11 Jul 2016 15:54
Last Modified: 11 Jul 2016 15:54
URI: http://eprints.abuad.edu.ng/id/eprint/1062

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