Ameliorative Potential of Sesamum indicum on Antioxidant Status of Liver and Brain of Experimental Rats in Textile Effluent-Induced Oxidative Stress

Babatunji, E. Oyinloye and Ojo, Oluwafemi A. and Osasona, Ilesanmi and Aderiye, Adedoyin S. and Ojo, Abiodun. A (2015) Ameliorative Potential of Sesamum indicum on Antioxidant Status of Liver and Brain of Experimental Rats in Textile Effluent-Induced Oxidative Stress. Advances in Biological Research, 9 (1). pp. 33-39. ISSN 1992-0067

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Abstract

The current study was carried out to evaluate the ameliorative potential of Sesamum indicum (SI) against textile effluent-induced toxicity in Wistar albino rats. Forty two rats (weighing 90-106 g) were divided into seven groups. Toxicity was induced by administering varying concentration of textile effluent as the main drinking water per day for 28 days. In the treatment experiment, aqueous extract of Sesamum indicum (200 mg/kg bw) was administered by oral gavage for 28 days. Physicochemical properties and heavy metal concentration of the effluent was analysed. Lipid peroxidation (LPO) and reduced glutathione (GSH) levels as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in the hepatic and brain tissues. Serum aminotransferase activities were also monitored. The results revealed that physicochemical properties and heavy metals concentration in the effluent were higher than the acceptable recommended maximum in drinking water. Animal exposure to the effluent resulted in significant elevation in the level of LPO with concomitant depletion in the level of GSH, CAT and SOD activities compared with control. In like manner, serum aminotransferase activities were elevated. Daily oral administration of Sesamum indicum showed beneficial and ameliorative effects in all biochemical parameter evaluated. The histopathological changes in the hepatic tissues were also monitored. The present study concluded that exposure of animals to varying concentrations of textile effluent could induce oxidative stress and treatment with aqueous extract of S. indicum (200 mg/kg bw) could ameliorate the hepatic and brain antioxidant status as well as biochemical indices of toxicity in animals exposed to textile effluent.

Item Type: Article
Uncontrolled Keywords: Brain Liver Oxidative Stress Sesamum Indicum Textile Effluent Toxicity
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 15 Jul 2016 14:28
Last Modified: 15 Jul 2016 14:28
URI: http://eprints.abuad.edu.ng/id/eprint/1094

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