Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties

Ademosun, A. O. and Oboh, G. and Adewuni, T. M. and Akinyemi, A. J. and Olasehinde, T. A. (2013) Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties. African Journal of Pharmacy and Pharmacology, 7 (33). pp. 2365-2358. ISSN 1996-0816

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Abstract

This study sought to compare the antioxidant properties [1,1-diphenyl–2 picrylhydrazyl (DPPH) and hydroxyl (OH) radicals scavenging abilities] and inhibition of Fe2+ -induced lipid peroxidation and two key enzymes relevant to type-2 diabetes (α-amylase and α-glucosidase) of snake tomato (Trichosanthes cucumerina) with two tomato varieties [Lycopersicon esculentum Mill. var. esculentum (ESC) and Lycopersicon esculentum Mill. var. cerasiforme (CER)]. Snake tomato (0.84 mg/g) and CER (0.87 mg/g) had significantly (P < 0.05) higher total phenolic content than ESC (0.27 mg/g). However, CER had the highest total flavonoid content of 0.48 mg/g, compared to snake tomato (0.27 mg/g) and ESC (0.15 mg/g). In consonance with the phenolic content, CER and snake tomato had higher DPPH and OH radicals scavenging abilities than ESC. The inhibition of Fe2+ induced malondialdehyde (MDA) production in rats pancreas revealed that snake tomato had significantly lower inhibitory effect than CER. Furthermore, snake tomato and CER showed stronger inhibition of α-glucosidase [snake tomato (EC50 = 1.65 mg/ml), CER (EC50 = 1.32 mg/ml)] than α-amylase [snake tomato (EC50 = 2.15 mg/ml), CER (EC50 = 2.39 mg/ml)] activity. The antioxidant properties of snake tomato favourably compared with the cultivars of tomatoes, and its stronger inhibition of α-glucosidase activity than α-amylase activities

Item Type: Article
Uncontrolled Keywords: Tomato, antioxidant, diabetes, flavonoids, α-amylase, α-glucosidase.
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QK Botany
Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 17 Aug 2016 10:36
Last Modified: 17 Aug 2016 10:36
URI: http://eprints.abuad.edu.ng/id/eprint/1184

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