Retarded hippocampal development following prenatal exposure to ethanolic leaves extract of Datura metel in wistar rats

Azeez, Olakunle Ishola and Philip, Adeyemi Adeniyi (2013) Retarded hippocampal development following prenatal exposure to ethanolic leaves extract of Datura metel in wistar rats. Journal of the Nigeria Medical Association, 54 (6). pp. 411-414.

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Abstract

Background: Datura metel contains atropine alkaloids and has been used to treat complication like asthma and, bronchitis, because of its anticholinergic properties. Aim: This study aimed to determine the prenatal effects of ethanolic extract of D. metel leaves exposure on the development of hippocampus. Materials and Methods: Twenty rats (12 females and 8 males) were purchased. The females were grouped into four groups (A_D). Group A were given 500 mg/kg body weight of the extract on the first day of fertilization to the end of gestation period, Group B were given 500 mg/kg body weight on the 8th day of fertilization to the end of gestation period, Group C were given 500 mg/kg body weight on 15th day of fertilization to the end of gestation period and Group D were given normal saline throughout the gestation period. Results: Rats in Group A showed no implantation, rats in Group B had abortion on the 7th day after administration, and rats in Group C gave birth with their litters showing retarded hippocampus development and neural degeneration and rats in Group D (control) showed normal development. Conclusion: Ethanolic extract of D. metel leaf is teratogenic in the late stage of pregnancy, is abortificient and can serve as a contraceptive.

Item Type: Article
Uncontrolled Keywords: Datura metel, fertilization, hippocampus, parturition, prenatal
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 26 Aug 2016 16:28
Last Modified: 26 Aug 2016 16:28
URI: http://eprints.abuad.edu.ng/id/eprint/1191

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