Effects Of Crude Extracts Of Portulaca Oleracea On Male Reproductive Functions In Albino Rats

Oyedeji, K.O and Bolarinwa, A.F (2013) Effects Of Crude Extracts Of Portulaca Oleracea On Male Reproductive Functions In Albino Rats. IOSR Journal of Pharmacy and Biological Sciences (IOSR - JPBS), 4 (6). pp. 71-79. ISSN 2278 - 3008

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Abstract

Portulaca oleraces i s a shrub which is grown as a vege table in many parts of the world. Many studies have reported the hypoxic nerve tissue protecti ve, anti - in flammatory and wound - healing effects of its extracts, but there is scanty information on its effect on reproduction. This study was designed to investigate the effect of its aqueous and methanolic extracts on reproductive parameters in male alb ino rats. Aqueous and methanolic extracts are designated as AEPO and MEPO respectively. AEPO and MEPO were prepared using cold maceration. The extracts at various doses (25 mg / g, 50mg / kg and 75 mg / kg) were orally administered for 50 days. Distilled wate r (0.5ml) served as the control. Plasma testosterone levels were assayed using Enzyme - linted I(mmunosorbent Assay (ELISA) and semen analysis was done microscopically, histology of the testes was also done. Dat a were analysed using ANOVA at p < 0.05. Treatm ent of rats with all the doses (except 25 mg / kg and 50 mg /kg AEPO) caused significant (p < 0.05) decrease in testosterone levels. Treatment of rats with all the doses (except 25 mg/kg AEPO) caused significant (p < 0.05) reduction in % progressive sperm mot ility, while treatment with al l the doses cause significant (p < 0.05) increase in % abnormal sperm cells. The extracts (AEPO and MEPO) also caused reductions of germinal epithelial cells. It can therefore be suggested that Portulaca oleracea has deleter ious effect on the reproductive functions in male albino rats

Item Type: Article
Uncontrolled Keywords: Portulaca oleracea, Testosterone, sperm count, Albino rats, Sperm motility
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 04 Jan 2018 11:25
Last Modified: 04 Jan 2018 11:25
URI: http://eprints.abuad.edu.ng/id/eprint/1383

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