EFFECT OF ISOLATED LUPONE CONSTITUENT OF PORTULACA OLERACEA ON REPRODUCTIVE PARAMETERS IN MALE RATS

Oyedeji, K.O and Bolarinwa, A.F and OLADOSU, I.A (2013) EFFECT OF ISOLATED LUPONE CONSTITUENT OF PORTULACA OLERACEA ON REPRODUCTIVE PARAMETERS IN MALE RATS. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (2). pp. 684-690. ISSN 0975-1491

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Abstract

Objective: This study was designed to evaluate the reproductive effect of isolated lupone constituent of Portulaca oleracea on reproductive parameters in male albino rats. Methods: The isolated compound was administered on daily basis for 25 days at doses of 0.50 mg/kg and 0.75 mg/kg and blood samples were collected for hormonal assay, semen analysis was also carried out. Data were analysed using ANOVA at p<0.05. Results: Treatment of rats with both doses caused decrease in testosterone levels, sperm motility and sperm count as well as significant (p<0.05) increase in the percentage of abnormal sperm cells relative to their respective controls. Conclusion: These findings on the reproductive parameters suggests that isolated lupone constituent of Portulaca oleracea has deleterious effect on reproductive functions in male albino rats.

Item Type: Article
Uncontrolled Keywords: Lupone, Sperm count, Sperm motility, Testosterone, Albino rats.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 04 Jan 2018 13:06
Last Modified: 04 Jan 2018 13:06
URI: http://eprints.abuad.edu.ng/id/eprint/1384

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