Evaluation of Haematological and Reproductive Effect of Paracetamol (Aceta minophen) In Female Abino Rats

Oyedeji, K.O and Bolarinwa, A.F and Adabanija, R.B. (2013) Evaluation of Haematological and Reproductive Effect of Paracetamol (Aceta minophen) In Female Abino Rats. IOSR Journal of Dental and Medical Sciences ( IOSR - JDMS), 3 (5). pp. 72-75. ISSN 2279 - 0861

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Abstract

The effect of oral administration of 7.5 mg/kg BW o f paracetamol on haematological and reproductive parameters in female albino rats were investigated. The paracetamol was administered by gavage on daily basis for haematological study, but administered orally for 21 day s for estrous cycle study. Treatment of rats with 7.5 mg/kg BW of paracetamol caused insignificant (p>0.05) changes in the RBC, PCV, H b , TWBC, platelet, neutrophil, lymphocyte, eosinophil, monocyte and haematmetric indices (MCV, MCHC, MCH) values relative to their respective controls. Treatment of rats with paracetamol (7.5 mg/kg BW) caused non - significant changes in the duration of all phases of estrous cycle relative to their respective controls. These findings probably indicates that paracetamol has no d eleterious effect on the blood chemistry and fertility of female albino rats.

Item Type: Article
Uncontrolled Keywords: Paracetamol, Red blood cell, Total white blood cell, Estrous cycle, Albino rats.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 04 Jan 2018 13:25
Last Modified: 04 Jan 2018 13:25
URI: http://eprints.abuad.edu.ng/id/eprint/1385

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