EFFECT OF ISOLATED TETRACYCLIC STEROID CONSTITUENT OF Portulaca oleracea ON REPRODUCTIVE PARAMETERS IN MALE RATS

Oyedeji, K.O and Bolarinwa, A.F and OLADOSU, I.A (2013) EFFECT OF ISOLATED TETRACYCLIC STEROID CONSTITUENT OF Portulaca oleracea ON REPRODUCTIVE PARAMETERS IN MALE RATS. Asian Journal of Pharmaceutical and Clinical Research, 6 (2). pp. 225-229. ISSN 0974-2441

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Abstract

The effect of oral administration of isolated tetracyclic steroid constituent of Portulaca oleracea at doses of 0.50 mg/kg BW and 0.75 mg/kg BW on reproductive parameters in male albino rats were investigated. The isolated compound was administered on daily basis for 25 days and blood samples were collected for hormonal assay, semen analysis was also carried out. Treatment of rats with 0.50 mg/kg BW and 0.75 mg/kg BW caused significant (p<0.05) decrease in testosterone levels, sperm motility and sperm count as well as significant (p<0.05) increase in the percentage of abnormal sperm cells relative to their respective controls. These findings on the reproductive parameters suggests that isolated tetracyclic steroid constituent of Portulaca oleracea has deleterious effect on reproductive functions in male albino rats.

Item Type: Article
Uncontrolled Keywords: Tetracyclic steroid, Sperm count, Sperm motility, Testosterone, Albino rats.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 05 Jan 2018 10:04
Last Modified: 05 Jan 2018 10:04
URI: http://eprints.abuad.edu.ng/id/eprint/1389

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