EFFECTS OF ALSTONIA BOONEI EXSTRACT ON HEMATOLOGICAL INDICES OF MALE WISTER RAT

Ojo, A.O. and Ojo, B.A. (2013) EFFECTS OF ALSTONIA BOONEI EXSTRACT ON HEMATOLOGICAL INDICES OF MALE WISTER RAT. PharmacologyOnline, 3. pp. 136-140. ISSN 1827-8620

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Abstract

DDVP (O, O-dimethyl-O- 2, 2-dichlorovinyl phosphate) is an organo-phosphate insecticide used in crop and food storage areas, greenhouses, barns and in workplaces. The present study examined hematology of Alstonia boonei stem bark extract in DDVP-induced experimental rats. Twenty male rats’ weight ranges 100- 190 g divided into four groups of five rats each. Group A were control rats, group B received DDVP only, group C received DDVP and 200 mg/kg dosage of extract and group D received DDVP and 400 mg/kg dosage of extract. Increasing doses (200 and 400 mg/kg body weight) of Alstonia boonei ethanol stem bark extract were administered by oral gavage to the other two treatment group C and D for 21 days. The animals were sacrificed using diethyl ether, and their blood sample collected into EDTA bottles, for assessing hemoglobin (Hb), red blood cell (RBC), packed cell volume (PCV), white blood cell (WBC), lymphocyte (L), monocytes (M), eosinophils (E), neutrophils (N), Mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). Statistical analyses of the results shows significant decrease in the hemoglobin and reverse all abnormalities in the hematological parameters when compared DDVP control with the extracts treated groups. In conclusion, Alstonia boonei ethanolic stem bark has a protective effect on blood profile againstthe DDVP toxicity

Item Type: Article
Uncontrolled Keywords: Hematology, Alstonia boonei, DDVP
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 27 May 2015 16:42
Last Modified: 27 May 2015 16:42
URI: http://eprints.abuad.edu.ng/id/eprint/159

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