Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits

Adeniyi, Philip Adeyemi and Olatunji, Babawale Peter and Ishola, Azeez Olakunle and Ajonijebu, Duyilemi Chris and Ogundele, Michael Ogundele (2014) Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits. Cadmium Increases the Sensitivity of Adolescent Female Mice to Nicotine-Related Behavioral Deficits, 2014 (10).

[img]
Preview
Text
360978.pdf

Download (1MB) | Preview
[img]
Preview
Image (ImageMagick conversion from text to image/tiff)
360978.tif

Download (41MB) | Preview
Official URL: http://dx.doi.org/10.1155/2014/360978

Abstract

This study investigates spatial and nonspatial working memory, anxiety related behavior, and motor activities in cadmium and/or nicotine exposed female adolescent mice. P28 female adolescent mice (albino strain) were divided into four groups of five () mice each. A set of mice (Nic) received subcutaneous nicotine (2.0 mg/kg) while a separate set (Cd) was treated with 2.0 mg/kg cadmium (subcutaneous). For the combined treatments of cadmium and nicotine, we administered 2.0 mg/kg Nicotine and 2.0 mg/kg of Cd. Subsequently, a separate group of animals (; control) received normal saline. The total duration of treatment for all groups was 28 days (P28–P56). At P56, the treatment was discontinued, after which the animals were examined in behavioural tests. Nicotine and cadmium increased the metabolism and food intake in the female adolescent mice. This also corresponded to an increase in weight when compared with the control. However, a combined nicotine-cadmium treatment induced a decline in weight of the animals versus the control. Also, nicotine administration increased the motor function, while cadmium and nicotine-cadmium treatment caused a decline in motor activity. Both nicotine and cadmium induced a reduction in memory index; however, nicotine-cadmium treatment induced the most significant decrease in nonspatial working memory.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 23 Dec 2014 17:15
Last Modified: 23 Dec 2014 17:15
URI: http://eprints.abuad.edu.ng/id/eprint/16

Actions (login required)

View Item View Item