Can serum concentration of C-reactive protein, albumin and body weight serve as an index of disease progression and treatment assessment in HIV/AIDS subjects?

Oluboyo, AO and Onyekachi, UN and Onyenekwe, CC and Oluboyo, BO and Chukwuanu, RC and Odiegwu, C N C and Chukwuma, G O and Onwuasoanya, U F (2013) Can serum concentration of C-reactive protein, albumin and body weight serve as an index of disease progression and treatment assessment in HIV/AIDS subjects? African Journals OnLine, 25 (3-4). pp. 101-106.

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Abstract

Background: Human immunodeficiency virus infection induces an acute phase response which is marked by changes in the plasma concentrations of acute phase proteins and a fall in CD4+T-cell counts and body weight. Objective: To determine whether serum concentration of C-reactive protein, serum albumin level and body weight can serve as an index of disease progression and treatment assessment in HIV/AIDS. Methodology: The study investigated 80 subjects (40 subjects on anti-retroviral therapy and 40 not on therapy) and 40 sero-negative subjects (control) attending the HIV/AIDS Clinic in Nnamdi Azikiwe Teaching Hospital, Nnewi, Nigeria. We determined serum concentrations of C-reactive protein, serum albumin levels and body weights. The C-reactive protein was estimated using semi-quantitative method, albumin level was estimated using bromocresol green method, and biuret method was used for total protein. The CD4+T-cell count of the subjects was determined using CyFlow Analyzer while their weights were measured using high precision weighing balance. Results: We observed that the mean weight (Kg), CD4+T-cells count (count/mm3), serum albumin (g/L), and total protein (g/L) of HIV subjects on therapy and those not on therapy were significantly lower (p<0.05) than in the control subjects. The mean C-reactive protein (mg/dL) was significantly higher in subjects on therapy compared to those not on therapies and the control subjects, p<0.05. Conclusion: In resource-poor regions or remote areas or villages where CD4+T-cell counts and viral load tests may not be available, the concentration of C-reactive protein, serum albumin level and changes in weight may serve as a reliable alternative marker for disease progression and treatment assessment for HIV subjects.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 13 Jul 2015 12:02
Last Modified: 13 Jul 2015 12:02
URI: http://eprints.abuad.edu.ng/id/eprint/237

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