Oluwafemi, Adeleke OJO and Basiru, Olaitan AJIBOYE and Babatunji, Emmanuel OYINLOYE and Adebola, Busola OJO and Olaide, Ibiwumi OLAREWAJU (2014) Protective effect of Irvingia gabonensisstem bark extract on cadmium-induced nephrotoxicity in rats. Interdisciplinary Toxicology, 7 (4). pp. 208-214.
Full text not available from this repository.Abstract
Cadmium has been considered a risk factor for humans as it accumulates in body tissues, such as the liver, lungs, kidneys, bones, and reproductive organs. The aim of the present study was to evaluate the effect of Irvingia gabonensis (IG) against cadmium (Cd)-induced nephrotoxicity. The study was performed on twenty (20) male rats divided into four groups: control group, cadmium group(4 mg/kg/day, intraperitoneally), cadmium + extract (200 mg/kg body weight by oral gavage) and cadmium + extract (400 mg/kg body weight by oral gavage). Changes in the kidney biochemical markers, namely glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), aminotransferase (ALT), aspartate aminotransferase (AST) activities and levels of malondialdehyde (MDA), urea, and creatinine were determined in serum. Histological examinations were monitored. Exposure to Cd lowered the activities of kidney antioxidants, while it increased LPO levels. Levels of all disrupted parameters were alleviated by co-administration of IG extract. The malondialdehyde concentration of the rats treated with 200 and 400 mg/kg body weight of the extract significantly decreased (p<0.05) compared with the untreated cadmium rats. Yet the creatinine concentration decreased significantly (p<0.05) when the cad-mium animals treated with 200 and 400 mg/kg body weight of the extract were compared with the cadmium control. Furthermore, histological alterations in the kidney were observed in cadmium untreated rats and these were ameliorated in cadmium treated rats by co-administration of IG extract. IG showed apparent protective and curative effect on Cd-induced nephrotoxicity
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cadmium, antioxidant, nephrotoxicity, Irvingia gabonensis, creatinin |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Mr. Victor Sebiotimo |
| Date Deposited: | 19 Mar 2019 09:55 |
| Last Modified: | 19 Mar 2019 09:55 |
| URI: | http://eprints.abuad.edu.ng/id/eprint/279 |
Actions (login required)
 |
View Item |
