In vitro antioxidant activities and inhibitory effects of phenolic extract of Senecio biafrae(Oliv and Hiern) against key enzymes linked with type II diabetes mellitus and Alzheimer’s disease

Ajiboye, Basiru O. and Ojo, Oluwafemi A. and Okesola, Marry A. and Akinyemi, Ayodele J. and Talabi, Justina Y. and Idowu, Olajumoke T. and Fadaka, Adewale O. and Boligon, Aline A. and Campos, Marli M. Anraku de (2018) In vitro antioxidant activities and inhibitory effects of phenolic extract of Senecio biafrae(Oliv and Hiern) against key enzymes linked with type II diabetes mellitus and Alzheimer’s disease. Food Science and Nutrition, 6. pp. 1-8.

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Abstract

The phenolic extract of Senecio biafraeleaves was investigated to determine the in vitro antioxidant, phenolic profiles, and inhibition of key enzymes relevant to type II diabetes mellitus (α- amylase and α- glucosidase) and Alzheimer’s disease (acetylcholinesterase and butrylcholinesterase). The phenolic extract demonstrated significant scavenging abilities against all in vitro antioxidant parameters assessed. Reversedphase HPLC of the extract revealed the presence of gallic acid, chlorogenic, caffeic acid, rutin, quercetin, and kaempferol. The extract also inhibited activities of α-amylase (IC 50 = 126.90 μg/ml), α- glucosidase (IC 50 = 139.66 μg/ml), acetylcholinesterase (IC 50 = 347.22 μg/ml), and butrylcholinesterase (IC 50 = 378.79 μg/ml), which may be attributed to the antioxidant potential of the extract and its phenolic composition. Therefore, this study suggests that the leaves of S. biafraemay be useful in the management of diabetes mellitus and Alzheimer’s disease.

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