Ajiboye, Basiru O. and Ojo, Oluwafemi A. and Adeyonu, Oluwatosin and Imiere, Oluwatosin D. and Fadaka, Adewale O. and Osukoya, Adetutu O. (2016) Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllusStem Bark on Pancreaticb-Cell Dysfunction in Alloxan-Induced Diabetic Rats. Journal of Evidence-Based Complementary & Alternative Medicine, 22 (4). pp. 1-6.
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Abstract
This study sought to investigate the ameliorative effects of ethanol extractArtocarpus heterophyllus(EAH) in alloxan-induced diabetic rats. The rats were divided into 6 groups, with groups 1 and 2 serving as nondiabetic and diabetic control, respectively; group 3 serving as diabetic rats treated with 5 mg/kg glibenclamide; and groups 4 to 6 were diabetic rats treated with 50, 100, and 150 mg/kg of EAH, respectively. Assays determined were serum insulin, lipid peroxidation, and antioxidant enzyme activities. EAH stem bark reduced fasting blood glucose and lipid peroxidation levels and increased serum insulin levels and activities of antioxidant enzymes. Data obtained demonstrated the ability of EAH stem bark to ameliorate pancreaticb-cell dysfunction in alloxan-induced diabetic rats.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Artocarpus heterophyllus, alloxan, diabetes |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mr. Victor Sebiotimo |
| Date Deposited: | 12 Apr 2019 11:58 |
| Last Modified: | 12 Apr 2019 11:58 |
| URI: | http://eprints.abuad.edu.ng/id/eprint/516 |
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