EFFECTS OF ALSTONIA BOONEIEXSTRACT ON HEMATOLOGICAL INDICES OF MALE WISTER RAT

Ojo, A. Oluwafem and Ojo, B. Adebola (2014) EFFECTS OF ALSTONIA BOONEIEXSTRACT ON HEMATOLOGICAL INDICES OF MALE WISTER RAT. EFFECTS OF ALSTONIA BOONEIEXSTRACT ON HEMATOLOGICAL INDICES OF MALE WISTER RAT, 3 (1). pp. 1-5. ISSN 1827-8620

Text
PhOL_2014_3_A019_Ojio_136_140_019.pdf - Published Version
Download (629kB)

Official URL: http://pharmacologyonline.silae.it

Abstract

DDVP(O,O-dimethyl-O-2,2-dichlorovinylphosphate)isanorgano-phosphateinsecticideusedincropandfoodstorageareas,greenhouses,barnsandinworkplaces.ThepresentstudyexaminedhematologyofAlstoniabooneistembarkextractinDDVP-inducedexperimentalrats.Twentymalerats’weightranges100-190gdividedintofourgroupsoffiveratseach.GroupAwerecontrolrats,groupBreceivedDDVPonly,groupCreceivedDDVPand200mg/kgdosageofextractandgroupDreceivedDDVPand400mg/kgdosageofextract.Increasingdoses(200and400mg/kgbodyweight)ofAlstoniabooneiethanolstembarkextractwereadministeredbyoralgavagetotheothertwotreatmentgroupCandDfor21days.Theanimalsweresacrificedusingdiethylether,andtheirbloodsamplecollectedintoEDTAbottles,forassessinghemoglobin(Hb),redbloodcell(RBC),packedcellvolume(PCV),whitebloodcell(WBC),lymphocyte(L),monocytes(M),eosinophils(E),neutrophils(N),Meancorpuscularvolume(MCV),meancorpuscularhemoglobin(MCH)andmeancorpuscularhemoglobinconcentration(MCHC).StatisticalanalysesoftheresultsshowssignificantdecreaseinthehemoglobinandreverseallabnormalitiesinthehematologicalparameterswhencomparedDDVPcontrolwiththeextractstreatedgroups.Inconclusion,AlstoniabooneiethanolicstembarkhasaprotectiveeffectonbloodprofileagainsttheDDVPtoxicity.

Item Type:	Article
Uncontrolled Keywords:	Hematology, Alstoniaboonei, DDVP
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Mr. Victor Sebiotimo
Date Deposited:	12 Mar 2019 15:33
Last Modified:	12 Mar 2019 15:33
URI:	http://eprints.abuad.edu.ng/id/eprint/71

Actions (login required)

View Item