Hepatoprotective Effect of Aqueous Extract of Solanum macrocarponLeavesagainst Carbon tetrachloride-Induced Liver Damage in Rats

Adewale, Olusola Bolaji and Oloyede, Omotade Ibidun and Onasanya, Amos and Olayide, Israel Idowu and Anadozie, Scholastica Onyebuchi and Fadaka, Adewale Oluwaseun Hepatoprotective Effect of Aqueous Extract of Solanum macrocarponLeavesagainst Carbon tetrachloride-Induced Liver Damage in Rats. Journal of Applied Pharmaceutical Science. ISSN 2231-3354

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Abstract

Liver damage is a growing concern of today’s modern society. The increasing incidence of exposure to toxic agents has contributed to liver diseases. There is therefore need for hepatoprotective agents. This study was aimed at investigating the protective effect of aqueous extract of the leaves of Solanum macrocarponagainst CCl4-induced liver damage in rats. Six groups of four animals each were used for the investigation. Group 1 served as control, groups 2, 3 and 4 animals were pre-treated with leaf extract of Solanum macrocarponat 250mg/kg, 500mg/kg and 750mg/kg body weight respectively for 14 days prior to a single intraperitoneal administration of CCl4. Animals in groups 5 and 6 received only the extract at a dose of 750mg/kg body weight and CCl4respectively. All animals were sacrificed 24 h after the administration of CCl4.The liver functions tests were performed in addition to their histopathological evaluation.Results obtained showed significant adverse changes in the levels of all measured parameters in CCl4treated rats. However, pre-treatment with aqueous extract of S. macrocarponprevented the adverse changes. Our findings suggest that S. macrocarponprotects the liver against CCl4-induced damage. This could be attributed to the presence of phytochemical compounds in the plant.

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