The Effects of Orally Administered Monosodium Glutamate (MSG) on Blood Thrombocyte, Blood Coagulation and Bleeding in Rats.

Ajibola, Meraiyebu and Oloruntoba, Akintayo Christopher and Chinomso, Uzoechi Adanma and Shekins, Okere (2012) The Effects of Orally Administered Monosodium Glutamate (MSG) on Blood Thrombocyte, Blood Coagulation and Bleeding in Rats. IOSR Journal of Pharmacy and Biological Sciences, 4 (1). pp. 1-5. ISSN 2278-3008

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Abstract

Monosodium glutamate (MSG) is a food additive, commonly consumed as a flavor enhancer. However, both animal models and human clinical reports have established its harmful effects. This work was carried out to study the effects of monosodium glutamate on blood thrombocytes, coagulation and bleeding time in adult male rats. The rats were divided into four groups: group 1 serves as the control group; group 2 was treated with 13.28g/kg bw of MSG (0.88%); group 3 was treated with 6.64g/kg bw of MSG (0.44%); group 4 was treated with 4.40g/kg bw of MSG (0.29%) for a period of 14 days respectively. Blood was taken via cardiac puncture for thrombocytes count, clotting and bleeding time were also taken. The results showed that there was a significant increase (p<0.05) in the number of platelets, bleeding time and clott ing time in rats treated with 13.28g/kg bw of MSG compared with their control counterpart which are indicative of thrombocytopenia and water retention.

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