Synthesis of 8-Methoxyquinoline and 5-Nitro-8-methoxyquinoline and their Biological Activities

Adewole, E. and Oke, T. O and Peters, O. A and Ogunmodede, O.T (2014) Synthesis of 8-Methoxyquinoline and 5-Nitro-8-methoxyquinoline and their Biological Activities. International Journal of Applied Research and Technology, 3 (12). pp. 40-47.


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Quinoline is a heterocyclic aromatic compound which serves as a feedstock for the synthesis of other and lead candidates of compounds having various pharmacological and herbicidal activities. 8-methoxyquinoline was synthesized using 8- Hydroxyquinoline as a starting material and the product yield was (815mg, 71%), the retardation factor was found to be 0.58, the IR showed aromatic absorption at 3049/cm, 892-649/cm. The 5-Nitro-8-Methoxyquinoline was also synthesized using 8-methoxyquinoline as starting material and the product percentage yield was 77% and melt at 1150C. The IR showed NO2 absorption at 1338/cm, aromatic absorption at 2914/cm, 930-620 /cm. The two products were screened for their biological activities. The 8-Methoxyquinoline showed strong antifungal activity against Aspergilius Flavus, Aspergilius nigea and Trichopython, also exhibited strong antibacterial activities against Bacillus substilis, Salmonella spp and Salmonella typhi than 5-Nitro-8-Methoxyquinoline. This biological properties exhibited by 8-methoxyquinoline showed that it may be a very good candidate for the synthesis of pharmaceutical products.

Item Type: Article
Uncontrolled Keywords: - Synthesis, 8-Methoxyquinoline, 5-Nitro-8-Methoxyquinoline, IR and Biological activities
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
T Technology > T Technology (General)
T Technology > TP Chemical technology
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Tayo Okunlola
Date Deposited: 26 May 2016 12:22
Last Modified: 26 May 2016 12:22

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