ANTI-FERTILITY ROLE OF ALLETHRIN BASED-MOSQUITO COIL ON ANIMAL MODELS

AKUNNA, G.G. and SAALU, L.C. and OGUNMODEDE, O.S. and AKINGBADE, A.M. (2013) ANTI-FERTILITY ROLE OF ALLETHRIN BASED-MOSQUITO COIL ON ANIMAL MODELS. International Journal of Biology, Pharmacy and Allied Science, 2 (2). pp. 192-207. ISSN 2277–4998

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Abstract

Here in this study, the testicular degeneration induced by allethrin-based mosquito coil was evaluated from evidences of sperm characteristics and testicular histology. Thirty male Wistar rats (10 to 12 weeks old) weighing 180-220 g were divided into three groups (A, B and C) of ten rats each. Group A served as the control while group B and C were exposed to allethrin-based mosquito coil for 16 weeks via whole body inhalation. The results obtained from this study showed a significant (P<0.005) decrease in the absolute and relative testicular weight of the models exposed to allethrin-based mosquito coil for 16 weeks compared to the control counterpart (180 ± 1.2 g Vs 216.2 ± 1. g). There was a significant reduction in their sperm count (51.6±1.5) and motility (25±9.2 %) but an increase in total abnormal sperm morphology (68.2±4.2 %) when compared to the values obtained from control (128.3±3.1, 82.1±5.2% and 28.4±4.6% respectively). In addition, the animals exposed to mosquito coil demonstrated a reduction of basal seminiferous epithelial cells, marked testicular atrophy, germinal aplasia and hypospermatozoa formation. There was a significant, progressive and clear degenerative change in their seminiferous tubule characterized by vacuolization of the interstitium and devoid of spermatozoa. Supported with evidences, this study extensively made known the degree of testicular derangement in wistar rat as a result of mosquito coil exposure

Item Type: Article
Uncontrolled Keywords: Anti-Fertility, Allethrin, Mosquito Coil, Testis, Lipid peroxidation, Spermatogenesis, Oxidative Stress
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 31 May 2016 13:18
Last Modified: 31 May 2016 13:18
URI: http://eprints.abuad.edu.ng/id/eprint/810

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