ANTIHYPOGLYCEMIC AND ANTIHYPOLIPIDEMIC ACTIVITIES OF ETHANOLIC ROOTS EXTRACT OF CROSSOPTERYX FEBRIFUGA IN ALLOXAN-INDUCED DIABETIC RATS.

OJEWALE, A.O. and OLANIYAN, O. T. and YEMITAN, O.K and ODUKANMI, O. A. and DARE, B. J. and NNAEMEKA, W.S. and OMOAGHE, O. and AKINGBADE, A.M. and OGUNMODEDE, O.S. and ADEBAR, A.O. (2013) ANTIHYPOGLYCEMIC AND ANTIHYPOLIPIDEMIC ACTIVITIES OF ETHANOLIC ROOTS EXTRACT OF CROSSOPTERYX FEBRIFUGA IN ALLOXAN-INDUCED DIABETIC RATS. Mintage Journal of Pharmaceutical & Medical Sciences, 2 (3). pp. 48-51.

[img]
Preview
Text
157.pdf

Download (411kB) | Preview
Official URL: http://mintagejournals.com

Abstract

Objective: The study investigated the activities of antihypoglycemic and antihypolipidemic of ethanolic roots extract of Crossopteryx febrifuga (CF) in alloxan-induced diabetic rats. Methods: Twenty male albino rats were randomly distributed to four groups; I, II, III and IV with each consisting of five animals received extracts as follows: Group I, C .febrifuga (500 mg/kg bwt); Group II, C.febrifuga (250 mg/kg bwt); Group III, C. febrifuga (100 mg/kg bwt); Group IV, 0.5 ml (2% w/v) acacia solution and served as control. After 30 min, the animals were each administered orally with 20% (w/v) glucose at a dose of 0.5ml /100 g bwt. Blood glucose levels were then monitored at 30, 60, and 120 min. intervals and reported as the average glucose level of each group. Twenty- Five (25) Albino rats were randomly divided into five (5) experimental groups: control, diabetic, standard drug (glibenclamide) and C. febrifuga (375 and 500 mg/kg bwt) treated diabetic groups. The animals in four out of five groups were fasted for 18 h and were made diabetic by injecting with a single dose of alloxan (ALX) 150 mg/kg. Blood was collected on days 0, 5, 10 and 15 for glucose estimation and day 15 for lipid profile assay. Results: A significant reduction in postprandial sugar level was observed after 60 min in all treatments. Alloxan-induced diabetic rats without treatment showed significant increases ( p < 0.05) in the levels of blood glucose, triglycerides, total cholesterol, low density lipoprotein LDL-cholesterol while the high density lipoprotein HDL-cholesterol level were significantly decreased ( p< 0.05) compared to normal rats. In addition, the diabetic rats treated with the CF and glibenclamide showed significant decrease ( p < 0.05) in both blood glucose, TG and LDLcholesterol levels and a significant decrease ( p < 0.05) in HDL-cholesterol level compared to diabetic untreated rats. Conclusion: The ethanolic roots extract of Crossopteryx febrifuga (CF) possesses potential hypoglycemic and hypolipidemic activities in alloxan-induced diabetic rats.

Item Type: Article
Uncontrolled Keywords: Crossopteryx febrifuga, glibenclamide, alloxan, hypoglycemic, hypolipidemic, postprandial.
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Tayo Okunlola
Date Deposited: 31 May 2016 15:27
Last Modified: 31 May 2016 15:27
URI: http://eprints.abuad.edu.ng/id/eprint/815

Actions (login required)

View Item View Item