Effect of Monosodium Glutamate on Behavioral Phenotypes, Biomarkers of Oxidative Stress in Brain Tissues and Liver Enzymes in Mice

Solomon, Umukoro and Gabriel, Oluwafemi Oluwole and Henry, Egbewunmi Olamijowon and Adrian, Itiviere Omogbiya and Anthony, Taghogho Eduviere (2015) Effect of Monosodium Glutamate on Behavioral Phenotypes, Biomarkers of Oxidative Stress in Brain Tissues and Liver Enzymes in Mice. World Journal of Neuroscience, 5. pp. 339-349.

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Abstract

The effects of oral administration of low doses of monosodium glutamate (MSG) on behavioral phenotypes, biomarkers of oxidative stress in the brain and liver enzymes in mice were evaluated in this study. Mice were treated orally with MSG (100, 250 and 500 mg/kg) daily for 21 days before testin g for behavioral phenotypes; memory, anxiety, spontaneous motor activity (SMA) and d e- pression. Thereafter, the brain levels of malondialdehyde (MDA) and glutathione (GSH) as well as the activities of liver enzymes, aminotransferase (AST) and alanine aminot ransferase (ALT) were determined spectrophotometrically. MSG did not produce significant ( P > 0.05) impairment of memory in the Y -maze test. It also failed to modify the behaviors of mice in the elevated plus maze and light/dark transition tests of animal models of anxiety. MSG had no significant effect on SMA but produced depressive-like symptoms in the forced swim test at a dose of 500 mg/kg. Moreover, it increased the levels of MDA and decreased GSH concentrations in brain tissues of mice. The a c- tivity o f AST and ALT were elevated in the blood of MSG -treated mice suggesting liver injury. Ta k- en together, these findings suggest ed that MSG induced oxidative stress in the brain and impaired liver functions but did not produce any behavioral abnormalities in ice at lower doses.

Item Type: Article
Uncontrolled Keywords: Monosodium Glutamate , Depression , Oxidative stress, Liver Enzymes
Subjects: Q Science > Q Science (General)
Q Science > QM Human anatomy
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Tayo Okunlola
Date Deposited: 01 Jun 2016 17:59
Last Modified: 01 Jun 2016 17:59
URI: http://eprints.abuad.edu.ng/id/eprint/829

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