Chukwuemeka, Kennedy Ikechukwu (2013) SERUM LEVELS OF ALKALINE PHOSPHATASE AND BONE MINERALS IN HIV-SEROPOSITIVE SUBJECTS IN NAUTH NNEWI. International Journal of Innovations in Medical Science, 3 (1). pp. 81-85.


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The high prevalence of bone demineralization among HIV-infected patients in the current therapeutic era has been reported in multiple studies, thus this study was designed to investigate the serum levels of the bone minerals (calcium, phosphate and magnesium) and alkaline phosphatase (ALP) activity in HIV-seropositive subjects. A total of 100 subjects (80 were HIV-seropositive and 20 were HIV-seronegative which served as the control subjects) were investigated. 40 HIV-seropositve subjects were on highly active antiretroviral therapy (HAART) and the remaining 40 HIV-seropositive subjects were not on HAART. Results showed that there was no significant difference (p>0.05) in the mean serum calcium levels between the control and case groups. The mean serum magnesium level of the control group was significantly higher (p<0.05) than that of the HIV-seropositive patients on HAART, also the mean serum magnesium level of HIV-seropositive patients on HAART was significantly higher (p<0.05) than the naïve HIV-seropositive patients. A significant higher (p<0.05) mean serum phosphate level was observed in the control group than in the HIV-seropositive subjects on HAART, but significantly higher (p<0.05) mean phosphate level was found in naïve HIVseropositive subjects than those on HAART. The mean serum ALP activity of both the naïve HIV-seropositive subjects and those on HAART was significantly higher (p<0.05) than the control subjects. In conclusion, there were significant alterations in the serum levels of calcium, magnesium, phosphate and ALP activity in both the naïve HIVseropositive subjects and those on HAART as compared to the age- and sex-matched HIV-seronegative control subjects. The highest incidence of alteration in serum levels of calcium and phosphate occurred in the naïve HIV-seropositive subjects, causing hypercalcaemia in 42.5% and hyperphosphataemia in 62.5% in the naïve HIVseropositive subjects. Nevirapine-containing HAART relatively caused the highest alteration in the serum levels of phosphate and ALP activity, causing abnormally high ALP activity in 25% and hyperphosphataemia in 20% of subjects on nevirapinecontaining HAART. On the other hand, zidovudine-containing HAART caused the highest alteration in serum calcium level in HIV-seropositive subjects on HAART, causing hypercalcaemia in 41.65% of subjects on AZT-containing HAART, while TDF-containing HAART caused hypocalcaemia in 15.38% of subjects on TDF containing HAART

Item Type: Article
Uncontrolled Keywords: bone, bone demineralization, bone minerals, human immunodeficiency virus (HIV), alkaline phosphatase (ALP), highly active antiretroviral therapy (HAART).
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 02 Jun 2016 12:42
Last Modified: 02 Jun 2016 16:06

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