Protein patterns in Nigerian men with prostate cancer

Adeola, Oluboyo and Samuel, Meludu and Charles, Onyenekwe and Bernard, Oluboyo and Ikemefuna, Uzochukwu and Chidi, Oranusi and Timothy, Mbaeri (2015) Protein patterns in Nigerian men with prostate cancer. Indian Journal of Basic and Applied Medical Research, 4 (3). pp. 102-107. ISSN 2250-284X

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Abstract

The increasing prevalence of prostate cancer is a challenge. Early detection and diagnosis of prostate cancer are vital in its management. Therefore the present study was designed to determine proteins that may be expressed in serum and urine of prostate cancer subjects. A total of fifty men diagnosed with prostate cancer and fifty healthy men (controls) were recruited for the study. Blood and urine specimen were collected from the subjects for the analysis of serum and urinary proteins using sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE). The proteins (kiloDalton) detected exclusively in the serum of prostate cancer subjects were p6.37 (8%), p9.18 (14%), p12.38 (12%), p13.38 (20%), p14.26 (6%), p16.0 (8%), p17.28 (4%), p22.36 (18%), p32.36 (30%), p34 (16%), p55.17 (6%), p64.26 (6%), p73.09 (8%), p91.08 (12%), p93.21 (4%), p94.06 (6%), p94.47 (12%) and p99.19 (10%) while p20.22 (8%) and p46.22 (8%) were detected in the urine of prostate cancer subjects. None of these proteins were expressed in the control subjects. The uses of these proteins alongside the estimation of the currently used markers may provide a strong lead way for the early detection and diagnosis of prostate cancer. Key words : prostate cancer, electrophoresis, serum protein, urine proteins

Item Type: Article
Uncontrolled Keywords: prostate cancer, electrophoresis, serum protein, urine proteins
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 02 Jun 2016 15:54
Last Modified: 02 Jun 2016 15:54
URI: http://eprints.abuad.edu.ng/id/eprint/840

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