Evaluation of four extracts from Dilleniaovata stem bark and leaves for antibacterial and antifungal activity

LIM, SWEE HUA ERIN and POON, PUI MUN and NG, SIEW LING and OH, CHAI PING and SIN, XIAO JIE and NG, SHI YING and LOH, TYI YNG and AYUBA, SUNDAY BURU and MALLIKAR, JUNA RAO PICHIKA (2013) Evaluation of four extracts from Dilleniaovata stem bark and leaves for antibacterial and antifungal activity. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (3). pp. 471-474. ISSN 0975-1491


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Background: Dillenia species are widely used by the indigenous people of Southeast Asia traditionally as it has many medicinal values. Dillenia sp. has been shown to possess antimicrobial and antioxidant properties but no studies have yet been carried out for D. ovata. Methods: In this study, the antimicrobial activity of n-hexane, ethyl acetate, methanol and water extracts of Dillenia ovata stem bark and leaf against twenty species of bacteria, fungi and yeasts was evaluated. The antimicrobial properties of D. ovata were evaluated through the disk diffusion method and the modified broth microdilution test using the resazurin assay. Results: In the disk diffusion assay, the most potent extract of Dillenia for both the stem bark and leaf was the n-hexane extract. A low concentration of the n-hexane extract was observed to be sufficient for the inhibition of bacterial growth compared to the methanol and ethyl acetate extracts. No antimicrobial activity was detected in the water extract for all strains tested and no inhibitory effects were observed for the fungal and yeast strains tested for all extracts. Conclusion: The compounds in the n-hexane extract will need to be elucidated further in order to investigate the efficacy of D. ovata as an antibacterial agent.

Item Type: Article
Uncontrolled Keywords: Dilleniaovata, Resazurin, Antimicrobial activity.
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 03 Jun 2016 11:34
Last Modified: 03 Jun 2016 11:34
URI: http://eprints.abuad.edu.ng/id/eprint/844

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