Antibacterial and antifungal testing of the different extracts of Dillenia obovata (Blume) Hoogl.

Ayuba, Sunday Buru (2013) Antibacterial and antifungal testing of the different extracts of Dillenia obovata (Blume) Hoogl. World Journal of Pharmacy and Pharmaceutical Sciences, 2 (5). 3946. -3962. ISSN 2278 – 4357

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Abstract

In the past decades, plants have been exploited as traditional therapeutic agents. This has led to recent studies which had been carried out on plants for investigations of their medicinal uses. The objective of this study was to evaluate and determine antimicrobial activity of different extracts from the stem bark and leaves of Dillenia obovata against five Gram-positive and six Gram-negative bacteria, seven yeasts and three fungi. Using disc diffusion method followed by broth microdilution, the results highlighted the most potent activity of hexane, ethyl acetate and methanol extracts of leaves were against Bacillus cereus with a minimum inhibition concentration of 0.0625mg/mL. Hexane, methanol, ethyl actetate and water extracts of stem bark and leaves exhibited broadest spectrum of antimicrobial activity against Gram-positive bacteria: Staphylococcus aureus, Bacillus cereus and Bacillus subtilis. Our findings suggest that D. obovata has the potential to be a good alternative to the conventional antimicrobial drugs which are usually associated with high toxicity and multiple side effects.

Item Type: Article
Uncontrolled Keywords: Dillenia; antimicrobial activity, disc diffusion, minimum inhibitory concentration, resazurin.
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Q Science > QR Microbiology > QR355 Virology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Mr Tayo Okunlola
Date Deposited: 03 Jun 2016 11:47
Last Modified: 03 Jun 2016 11:47
URI: http://eprints.abuad.edu.ng/id/eprint/845

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