Effect of aqueous extract of Talinum triangulae (water leave) in lead- induced chromosomal aberration

Afolabi, Olakunle B. and Oloyede, O.I and Oladimeji, Tugbobo (2014) Effect of aqueous extract of Talinum triangulae (water leave) in lead- induced chromosomal aberration. The Journal of Phytopharmacology, 3 (4). pp. 238-241. ISSN 2230-480X

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Official URL: http://phytopharmajournal.com

Abstract

Phytomedicine is a subject that is now gaining relevance worldwide aiding treatment for diseases that were once incurable among folks in which genotoxicity is a prominent one. The present study was designed to examine the ability of Talinum triangulare (water leaf) to protect the genomic integrity of swiss albino rat from lead-induced chromosomal damage in the bone marrow red blood cells. 20 eight week old rats were divided into five groups with group 1 as the negative control and group 2 is the positive control and the other groups, all treated by gavage once per day with a single dose of 2.5 mg/ml lead acetate. The frequency of micronuclei formed was examined in the bone marrow erythroblast of the treated and untreated groups through standard micronuclei assay method. The plant shows significant (p<0.05) difference in genoprotective ability in the group treated with 200 mg/kg body weight of the aqueous extract of the plant over 100 and 400 mg/kg b.w when the level of the micronucleated proerythroblast formed in the bone marrow was considered and a substantial decrease in the number of polychromatophilic erythroblasts (PCEs) scored from the stained blood cells in the groups respectively. It is shown in the present study that lead-induced chromosomal damage could be averted measurably by dietary consumption of Talinum triangulare.

Item Type: Article
Uncontrolled Keywords: Talinum triangulare, Genotoxicity, Micronuclei, Polychromatophilc, Erythroblast.
Subjects: Q Science > Q Science (General)
Q Science > QK Botany
S Agriculture > S Agriculture (General)
S Agriculture > SD Forestry
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Tayo Okunlola
Date Deposited: 16 Jun 2016 13:15
Last Modified: 16 Jun 2016 13:15
URI: http://eprints.abuad.edu.ng/id/eprint/954

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