Evaluation of Risk Factors of Cardiovascular Disease on Hypertensive Post-Menopausal Women and Aged-matched Hypertensive Males.

Amah, U.K and Obianyia, VE and Meludu, SC and Onah, CE and Olisakodiaka, JM and Onuegbu, JA and Okwara, JE and Amah, AK and Okwara, EC and Oluboyo, AO (2014) Evaluation of Risk Factors of Cardiovascular Disease on Hypertensive Post-Menopausal Women and Aged-matched Hypertensive Males. Evaluation of Risk Factors of Cardiovascular Disease on Hypertensive Post- Menopausal Women and Aged-matched Hypertensive Males, 2 (4). pp. 1-8. ISSN (e)-2347-176x

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Abstract

Background: This study compared plasma lipids and glucose levels in hypertensive post -menopausal women with age-matched hypertensive men. Methods: This is a cross sectional study that involves 100 subjects attending out-patient department of Nnamdi Azikiwe University Teaching hospital hypertensive clinics and control subjects. 25 hypertensive post-menopausal women and 25 hypertensive male subjects both within the same age range of 50-60 years. Also 25 hypertensive pre-menopausal women and 25 nonhypertensive controls both within the age range of 30-40 years. The lipid profile parameters (Total Cholesterol (TC), Triglyceride (TG), Low density Lipoprotein (LDL-C), and High Density Lipoprotein (HDL-C)) and fasting plasma glucose were determined using standard methods. The study also assessed the anthropometric indices such as BMI, SBP and DBP in each group. Results: The mean levels of TC and TG were significantly lower in post-menopausal hypertensive females when compared with the hypertensive males (p<0.05). However, the mean plasma HDL-C and LDL-C did not show any significant difference between the two groups. The comparison of the mean levels of all the parameters in hypertensive males with the non-hypertensive controls showed a significant difference (P < 0.05). The mean levels of TC and LDL-C were significantly higher in hypertensive post-menopausal women when compared with hypertensive pre-menopausal females (P<0.05). Conclusion: This study showed that menopause had altered the plasma lipids of the hypertensive post -menopausal women, but not to the extent of putting them at the same atherosclerosis scale as their male counterpart.

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