The Incidence of Diabetes Mellitus among Human Immunodeficiency Virus (HIV) Positive Patients on Therapy in Nnewi.

Chukwuanukwu, R.C and Manafa, P.O and Ugwu, E.E and Onyenekwe, C.C and Oluboyo, A.O and Ezeugwunne, I.P and Ogenyi, S.I (2013) The Incidence of Diabetes Mellitus among Human Immunodeficiency Virus (HIV) Positive Patients on Therapy in Nnewi. IOSR Journal of Nursing and Health Science, 2 (3). pp. 1-4. ISSN online (2320–1959); (print)2320–1940

Text F0233740.pdf - Published Version Download (449kB)

Abstract

Diabetes Mellitus (DM) is a common disorder affecting individuals of all ages. Similar to general population, diabetes mellitus (DM) can also be seen in HIV infected subjects. In this study, 150 confirmed HIV positive subjects, 50 of whom were on the first line drug of Lamividine, Nevirapine, Combivir, Co mbipack and efavirenze were recruited. The second group of 50 subjects was on second line drugs which consisted of Truvada and Aluvida. Truvada is from first line drug and comprises tenofovir and emtricitabine while aluvida is protease inhibitor and comprises lopinavir and ritonavir. The third group of 50 subjects was not on antiretroviral therapy and was used as control. All the patients were screened for diabetes mellitus (DM) before the commencement of antiretroviral therapy and found to be negative. Assay was performed three months after the commencement of therapy. There is a prevalence of 6% diabetes mellitus in those on second line drugs which comprised mostly protease inhibitors compared to 0% of those on the first line drug and control samples using a cut-point of 11.0 mmol/L of random blood sugar as recommended by World Health Organization (WHO). It is possible that the rise in blood glucose level may be a result of Aluvida , a protease inhibitor rather than Truvada a first line drug. There is also a prevalence of 10% impaired glucose intolerance based on WHO cut-point of 8.0mmol/l. Most of the patients recruited for this work had CD4 less than 350 cells/ l, which is the WHO cut point before drug can be administered to a patient. Therefore primary care for HIV – infected individuals with reference to DM and its complication is important.

Actions (login required)

View Item