Hearing loss molecular analysis

Aremu, Shuaib Kayode and Rasaq, Adewoye Kayode and Omotosho, Wasiu (2018) Hearing loss molecular analysis. Edorium Journal of Otolaryngology, 4. pp. 1-5.

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Abstract

In the past it was difficult to identify children with hearing loss, and many newborns remained undiagnosed, but since early 2000, when Universal Newborn Hearing Screening (UNHS) came into place and made successful strides in hearing loss research and have been able to provide screening of hearing loss at an early age of one month, hence they have been able to receive comprehensive treatment. UNHS also tracks infants for further follow up and wherever necessary. The two main methods used in newborn screening are otoacoustic emission and automated auditory brain stem response. Medical evaluation should begin as soon as possible when hearing loss is suspected, so as to complete prenatal, medical, and family history. Demands have been made to use DNA testing in detecting the molecular basis of hereditary hearing loss. The identification of genes and gene defects faces a lot of challenges due to the fact, there is tremendous genetic heterogeneity, but despite that, there has been successful genetic studies of hearing loss in isolated populations and consanguineous families. Hearing loss is common in patients with mitochondrialdisorders, affecting over half of all cases at some time in the course of the disease. Hearing loss has seen some research undertaken to the point now that deafness can be treated and this is through cochlea implantation.

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