T LYMPHOCYTE SUBSETS IN PROSTATE CANCER SUBJECTS IN SOUTH EASTERN NIGERIA

Oluboyo, A.O and Oluboyo, B.O (2016) T LYMPHOCYTE SUBSETS IN PROSTATE CANCER SUBJECTS IN SOUTH EASTERN NIGERIA. AFRICAN JOURNAL OF CLINICAL AND EXPERIMENTAL MICROBIOLOGY, 17 (3). pp. 1-4. ISSN 1595-689X

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Abstract

Humoral and cellular mechanisms play roles in immune response to foreign antigens. The present study was designed to determine the T lymphocyte subsets (CD4 + T cells, CD8 + T cells and CD4/CD8 ratio) in the prostate cancer subjects and control subjects. CD4 + T cells (µl/count) and CD8 + T cells (µl/count) were estimated using flow cytometric method by Partec while CD4/CD8 ratio was calculated from the resultsobtained from the CD4 + T cells and CD8 + T cells.CD4 + T cells and CD8 + T cells decreased significantly while the CD4/CD8ratio increased significantly in the prostate cancer subjects compared to the control subjects. The suppressed CD4 + and CD8 + T cell counts in prostate cancer subjects may indicate immune instability in the prostate cancer subjects.

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