THE IMPACT OF MIMOSA PUDICA ON THE HISTOARCHITECTURE OF HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS IN CADMIUM TREATED RATS

Ekpenyong, Edem Edem and Anderson, Enye Linus and Abdullateef, Towobola Adewale and Akingbade, Adebanji Modupe and Kunlere, Oladunni Eunice (2015) THE IMPACT OF MIMOSA PUDICA ON THE HISTOARCHITECTURE OF HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS IN CADMIUM TREATED RATS. THE IMPACT OF MIMOSA PUDICA ON THE HISTOARCHITECTURE OF HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS IN CADMIUM TREATED RATS, 4 (10). pp. 1-17. ISSN 2278 – 4357

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Abstract

Background: Cadmium is a known environmental and industrial pollutant with an enormous neuroendocrine disrupting potential. Mimosa pudica Linn is a creeping annual or perennial herb known to possess antiasthmatic, antiepileptic, antitumour, aphrodisiac, analgesic, antidepressant properties and a strong radical scavenging activity. This research was aimed at investigating the impact of Mimosa pudica on the histoarchitectural integrity of the hypothalamic-pituitary-testicular axis in cadmium-treated rats. Materials and Methods: Twenty five mature wistar rats (Rattus rattus norvegicus) were employed in the study. These animals were divided into five groups - 5 Rats/Group; Control, Cadmium Toxicity, Mimosa pudica Extract, Protection and Therapeutic Groups. The Control Group was orally administrated with distilled water. Result: Toxicity was achieved with 1.2mg/kg body weight for forty days with apparent histological abnormalities and alterations to the axis components. Administration of Mimosa pudica (200mg/kg) body weight with cadmium in both the Protection and Therapeutic Groups showed remarkable histological improvements and markedly reduced tissue damage when compared with Cadmium Toxicity Group. Conclusion: Results of this study demonstrate that Mimosa pudica possesses protective, therapeutic as well as restorative capacity on the histoarchitecture of hypothalamic-pituitary-testicular axis components in cadmium-treated rats.

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