Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats

Ojo, Rotimi Johnson and Memudu, Adejoke Elizabeth and Akintayo, Christopher Oloruntoba and Akpan, Idongesit Sunday (2012) Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats. Effects of Pre-induction Administration of Allium Sativum on Some Biochemical Parameters in Alloxan Induced Diabetic Rats, 4 (23). pp. 1-7. ISSN 2040-7467

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Abstract

The aim of the present study was to investigate the effects of pre- and post- administration of garlic extract on serum glucose and some biochemical parameters in alloxan-induced diabetic rats to show the preventive and ameliorating effects in alloxan induced-diabetic rats. Rats were divided into 4 groups; normal control rats, diabetic control rats, diabetic rats post-treated with garlic extract and rats pre-treated with garlic extract before induction. Garlic extract was administered orally for 2 weeks to post-treated rats and 3 weeks to pre-treated rats and they were compared with the normal and diabetic groups, respectively. Serum glucose was reduced significantly in both post-treated and pre-treated groups. The post-treatment with garlic extract reduced serum cholesterol, but pre-treatment with garlic extract produced significant change compare to the diabetic control. The serum creatinine and urea levels were significantly reduced in post-treated group and pretreated group compare to the diabetic control group. It is concluded that the consumption of garlic produced a significant hypoglycaemic and hypolipidemic effects in diabetic rats and also, garlic is capable of protecting the liver and the kidney functions in alloxan-induced diabetic rats as shown in the activities of serum enzymes and other biochemical parameters examined.

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