Fertility Hormones, CD4+T Cells and CD8+Tcells In HIV Seropositive Subjects In Onitsha, Nigeria

Oluboyo, A.O and Ihejimkpo, A.E and Onyenekwe, C.C and Oluboyo, A.O and Amah, U.K and Okwara, J.E and Ogenyi, S. I and Onyemelukwe, A.O (2013) Fertility Hormones, CD4+T Cells and CD8+Tcells In HIV Seropositive Subjects In Onitsha, Nigeria. Fertility Hormones, CD4+T Cells and CD8+Tcells In HIV Seropositive Subjects In Onitsha, Nigeria, 1 (1). pp. 1-4.

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Abstract

Human immunodeficiency Virus (HIV) infection and Acquired immunodeficiency syndrome (AIDS) have become global health concern. The uses of antiretroviral therapy (ART) have been shown to improve health but are associated with a wide array of immunologic, endocrinologic and metabolic abnormalities. This study determined the levels of fertility hormones, CD4 and CD8+Tcells in HIV seropositive subjects and seronegative subjects. A total of one hundred and seventy HIV seropositive subjects were investigated while fifty HIV seronegative subjects served as controls. Eighty-five HIV seropositive subjects were on antiretroviral therapy consisting of three drug combinations (Zidovudine 300mg twice daily; Lamivudine 150mg twice daily; Tenofovir 300mg once daily; Efavirenz 600mg once daily and Stavudine 30mg twice daily for body weight of <60kg or 40mg twice daily for body weight of >60kg). Eighty five HIV seropositive subjects were not on antiretroviral therapy. Fertility hormones (Follicle Stimulating Hormone, Leutinising Hormone, Prolactin and Testosterone) were determined using Enzyme linked immunosorbent assay (ELISA) method. CD4+Tcells and CD8+Tcells were determined using flow cytometry. The serum levels of the fertility hormones in HIV seropositive males on antiretroviral therapy (ART) and those not on ART showed significant reduction (P<0.05) when compared with that of HIV seronegative male control subjects. The serum levels of the hormones in HIV seropositive females on ART and those not on ART showed no significant difference compared with those of HIV seronegative control female subjects. The CD4+T cell counts of HIV seropositive male and female subjects on ART and those not on ART showed significant reduction (P<0.05) when compared with the HIV seronegative control subjects. There was significant increase in the levels of CD8+T cell counts of the HIV seropositive males and females on ART. HIV infection is associated with variations in the male hormonal fertility profiles but without significant effect on women hormonal fertility profiles. However, CD4+Tcells decrease while CD8+T cells increase as HIV/AIDS progresses.

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